ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES

摘要

The invention is directed to compounds according to formula (I):where R₁ is L₁C(O)OT or L₁C(O)OL₂C(O)OT; R₂ is a substituted or unsubstituted C₁-C₁₀ alkyl, C₂-C₁₀ alkenyl, or C₂-C₁₀ alkynyl, or R₁; n is an integer from 0 to 5; each R₃ is independently halogen or R₂; L₁ and L₂ are each independently a bond, a substituted or unsubstituted C₁-C₁₀ alkylene, C₂-C₁₀ alkenylene, or C₂-C₁₀ alkynylene; and T is H, a substituted or unsubstituted C₁-C₁₀ alkyl, C₂-C₁₀ alkenyl, or C₂-C₁₀ alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.