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PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSTIC
PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSTIC
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机译:甲基化富集产前诊断胎儿样品中胎儿核酸的甲基化富集过程和组成
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摘要
Provided is a method for determining the amount of fetal nucleic acid in a sample comprising: a) contacting nucleic acid present in a sample from a pregnant female, which sample comprises differentially methylated fetal nucleic acid and maternal nucleic acid, with an agent that specifically binds methylated nucleotides; thereby producing bound nucleic acid; b) isolating the bound nucleic acid of (a), thereby enriching the fetal nucleic acid; and c) determining the amount of fetal nucleic acid by analyzing the amount of fetal nucleic acid of (b) at a plurality of loci selected from loci of SEQ ID NOs:1-89.
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机译:提供了一种确定样品中胎儿核酸的量的方法,该方法包括:a)使来自怀孕女性的样品中存在的核酸与特异性结合的试剂接触,所述样品包含差异甲基化的胎儿核酸和母体核酸。甲基化核苷酸;从而产生结合的核酸; b)分离(a)的结合核酸,从而富集胎儿核酸; c)通过分析选自选自SEQ ID NOs:1-89的基因座的多个基因座上的(b)的胎儿核酸的量来确定胎儿核酸的量。
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