STEM CELLS FOR ANTIANGIOGENIC THERAPY IN AGE-RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, CORNEAL ANGIOGENESIS, AND CANCER

摘要

PROBLEM TO BE SOLVED: To provide stem cells expressing antiangiogenic proteins.SOLUTION: The present invention provides stem cells that inhibit angiogenesis in the human body. The stem cells are genetically engineered mesenchymal stem cells (MSC) comprising a recombinant vector carrying the vascular endothelial growth factor receptor (VEGFR) gene and expresses a VEGFR polypeptide. The stem cells are those used to inhibit angiogenesis for treatment in patients suffering from macular degeneration, corneal angiogenesis, cancer, diabetic retinopathy, lymphangiogenesis, retinal neovascularization, thyroid hyperplasia, preeclampsia, rheumatoid arthritis and osteoarthritis, Alzheimer's disease, obesity, pleural effusion, atherosclerosis, endometriosis, and choroidal neovascularization. In the stem cells, the VEGFR gene is VEGFR1, the VEGFR polypeptide is a soluble form of VEGFR, and the VEGFR polypeptide is human FLT-1 protein.SELECTED DRAWING: Figure 2