RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-BINDING PROTEIN) β1(CTNNB1) GENE EXPRESSION USING SMALL INTERFERING NUCLEIC ACID (SINA)

摘要

PROBLEM TO BE SOLVED: To provide a compound, composition, and method for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of cadherin-binding protein β1(CTNNB1) gene expression and/or activity, and/or modulate a β-catenin gene expression pathway.;SOLUTION: The present invention provides a double-stranded nucleic acid molecule that is capable of mediating or that mediates RNA interference (RNAi) against CTNNB1 gene expression, examples of such a molecule including, for example, a double stranded short interfering nucleic acid (siNA) having a specific nucleotide sequence. The siNA is a double-stranded short interfering nucleic acid (siNA) molecule comprising a sense strand and an antisense strand.;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2017,JPO&INPIT