A method for determining a structural profile that reflects its stability of a fibrin clot for the purpose of predicting the risk of bleeding, thrombosis or rethrombosis

摘要

The present invention provides a method for dynamically determining a structural profile of a fibrin clot that reflects its stability in a biological sample of a patient comprising the steps of: a) contacting an undiluted biological sample with a tissue factor, Or a mixture of tissue factor and tissue plasminogen activator; b) incubating the mixture obtained in step a) and then adding calcium ions (5 l) to the resulting mixture to initiate the formation of a fibrin clot C) measuring the turbidity or optical density of the clot being formed in step b) for at least two wavelengths between 450 nm and 850 nm for 1 to 35 minutes; d) ⁵= A [Fg]. (²Determining the structural profile of the analyzed clot, represented by the number, density and radius of the protofibrils, by means of-F);Selection drawing None