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Method for determining medullary thyroid cancer

机译:确定甲状腺髓样癌的方法

摘要

PROBLEM TO BE SOLVED: To provide a method for determining presence or absence of medullary thyroid cancer, which can specifically detect medullary thyroid cancer.SOLUTION: A method for determining presence or absence of medullary thyroid cancer uses a method having a process (a) for detecting expression of a splicing variant of CEACAM4 gene such as a cDNA composed of a specific base sequence in a sample for determination or the splicing variant such as a protein composed of an amino acid sequence encoded by the base sequence, etc., and a process (b) for evaluating that possibility of a sample donor for determination having medullary thyroid cancer is high when the expression of the splicing variant of CEACAM4 gene or a protein encoded by the splicing variant is detected in the process (a).
机译:解决的问题:提供一种确定甲状腺髓样癌是否存在的方法,该方法可以特异性地检测甲状腺髓样癌。解决方案:一种确定甲状腺髓样癌的存在或不存在的方法采用具有以下过程的方法(a)检测CEACAM4基因的剪接变体(例如由特定碱基序列组成的cDNA)在待测定样品中的表达或剪接变体(例如由该碱基序列编码的氨基酸序列组成的蛋白质)的表达,以及方法(b)用于评估当在步骤(a)中检测到CEACAM4基因的剪接变体或由剪接变体编码的蛋白的表达时,确定供体的甲状腺髓样癌的可能性较高。

著录项

  • 公开/公告号JP6145657B2

    专利类型

  • 公开/公告日2017-06-14

    原文格式PDF

  • 申请/专利权人 静岡県;

    申请/专利号JP20130092295

  • 申请日2013-04-25

  • 分类号C12N15/09;C07K14/705;C12Q1/68;G01N33/574;

  • 国家 JP

  • 入库时间 2022-08-21 13:56:42

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