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Piperacillin sodium and sulbactam sodium eutectic, process for producing the same, pharmaceutical composition containing the eutectic and its application
Piperacillin sodium and sulbactam sodium eutectic, process for producing the same, pharmaceutical composition containing the eutectic and its application
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机译:哌拉西林钠和舒巴坦钠共晶物,其制备方法,包含该共晶物的药物组合物及其应用
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摘要
Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by drug-resistant bacteria, such as a "super bacterium" producing NDM-1 and the like. The cocrystal of piperacillin sodium and sulbactam sodium contains diffraction angles of 14.24°, 16.58°, 16.79°, 17.77°, 19.20°, 20.21°, 20.39°, 23.06°, 27.86° and 32.16° represented by 2¸ in an X-ray powder diffraction analysis spectrum.
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