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Ex Vivo Browning of Adipose Tissue Therapy for Reversal of Obesity and Type II Diabetes
Ex Vivo Browning of Adipose Tissue Therapy for Reversal of Obesity and Type II Diabetes
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机译:肥胖和II型糖尿病逆转的脂肪组织治疗的体内褐变
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摘要
Provided are methods, apparatus, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes, by administration to a subject of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues or brown adipose tissue directly converted from white adipose tissue. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue and direct browning of white adipose tissue in a bioreactor rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3D cell aggregates.
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