stable composition of the inactivated chikungunya virus strain vaccine with one or more mutations; method for inducing a protective immune response in human individuals against chikungunya virus infections; use of chikungunya virus isolates; combined vaccine composition

摘要

stable composition of the inactivated chikungunya virus strain vaccine with one or more mutations; method for inducing a protective immune response in human individuals against chikungunya virus infections; use of chikungunya virus isolates; Combined vaccine composition A vaccine composition for the prophylaxis and treatment of chikungunya virus infections is described and capable of granting immunity against any genotypic variants of the chikungunya virus. more particularly, the invention describes particular nucleotide sequences and their translated proteins, which may be expressed as virus-like particles for use as vaccine antigens against chikungunya virus infections. The compositions described in this invention are also protective against any genotypic variants of the chikungunya virus that may be propagated by any suitable disease vector including aedis albopictus and aedis aegypti.