首页> 外国专利> Method for the treatment of an individual in need of a graft cell singu00eanico or tissue, a method to treat an individual who needs a transplant of immature hematopoietic cells.Method for inducing donor specific tolerance in an individual's needs, a cell singu00eanica or graft of tissue.And method to treat a person who needs a cell or tissue graft singu00eanica

Method for the treatment of an individual in need of a graft cell singu00eanico or tissue, a method to treat an individual who needs a transplant of immature hematopoietic cells.Method for inducing donor specific tolerance in an individual's needs, a cell singu00eanica or graft of tissue.And method to treat a person who needs a cell or tissue graft singu00eanica

机译:一种用于治疗需要移植细胞或组织的个体的方法,一种用于治疗需要移植未成熟造血细胞的个体的方法。一种用于在个体需要中诱导供体特异性耐受的方法,一种细胞。或组织移植物。以及治疗需要细胞或组织移植物的人的方法

摘要

A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.
机译:公开了一种治疗需要非同基因细胞或组织移植物的受试者的方法。所述方法包括:(a)将消耗一定剂量的T细胞的未成熟造血细胞移植到受试者中,其中所述消耗掉T细胞的未成熟的造血细胞包含每千克受试者体重少于5×105个CD3 + T细胞,并且其中所述剂量每千克受试者体重包含至少约5×106个CD34 +细胞;随后(b)向受试者施用治疗有效量的环磷酰胺,其中所述治疗有效量包括每千克体重25-200mg,从而治疗受试者。

著录项

  • 公开/公告号BR112014015959A8

    专利类型

  • 公开/公告日2017-06-13

    原文格式PDF

  • 申请/专利权人 YEDA RESEARCH AND DEVELOPMENT CO. LTD.;

    申请/专利号BR20141115959

  • 发明设计人 ESTHER BACHAR-LUSTING;YAIR REISNER;

    申请日2012-12-20

  • 分类号A61K39/395;A01N63;A61K35/22;A61K35/28;A61K35/34;A61K35/36;A61K35/38;A61K35/39;A61K35/407;A61K35/42;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:28

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