process for purifying circumsporozoite protein e.g. recombinant falciparum; stable liquid formulation of circumsporozoite protein e.g. recombinant falciparum; and process for stably maintaining rcsp in a stable liquid formulation

摘要

abstract “process for purifying circumsporozoite protein p. recombinant falciparum; stable liquid formulation of circumsporozoite protein e.g. recombinant falciparum; and Process for Stably Maintaining Rcsp in a Stable Liquid Formulation ”are processes for purifying high quality recombinant circumsporozoite protein plasmodium falciparum in high yield. This process provides high yield rcsp without the need to denature and refold the protein. The present invention overcomes obstacles previously encountered in the field, including dimerization aggregation and n-terminal degradation of rcsp. The process provided by the invention is scalable and can be applied to large batches of fermentation. The invention also relates to stable liquid formulations of circumferozoite protein e.g. recombinant falciparum, and processes for stably maintaining rcsp in a stable liquid formulation.