process for preparing an oxycodone adduct, aqueous oxycodone adduct aqueous solution, solid oxycodone acid adduct, and solid oxycodone alkaloid

摘要

1/1 summary â € œprocess for preparing an acid oxycodone adduct, aqueous acid oxycodone adduct solution, solid acid oxycodone adduct, and solid oxycodone alkaloid The present invention provides a process for the preparation of an acid oxycodone adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid for form an acid - oxycodone adduct solution, wherein hydrogenation is performed at one or more temperatures above room temperature in the presence of a hydrogenation and gas catalyst Hydrogen, wherein the acid oxycodone adduct solution comprises 6Î ± -oxycodol in an amount â ¤ about 0.800% in area as determined by hplc.