3- (aryl or heteroaryl) methyleneindolin-2-one derivatives as cancer stem cell signaling pathway kinase inhibitors for cancer treatment

摘要

Abstract "3- (Aryl or heteroaryl) methyleneindolin-2-one derivatives as cancer stem cell signaling pathway kinase inhibitors for the treatment of cancer" The present invention provides compounds of formula I as inhibitors of cell as well as cancerous stem cell signaling pathway kinase and other related kinases, pharmaceutical compositions and their use in the treatment of cancer or a related disorder in a mammal, where, among others, r2 is an optionally substituted heterocycle or optionally substituted aryl; and one of r4, r5, r6 and r7 is a substituted heterocycle or substituted aryl.