transgenic non-human animal, progeny of animal, method for identifying a compound, method for selecting specificity or selectivity for binding of a candidate compound, immortalized cell, tissue or cell line, use of immortalized cell, tissue or cell line, method for identification of a compound, method for filtering the binding specificity or selectivity of a candidate compound, and use of a compound of general formula

摘要

The present invention relates to transgenic animal models. Specifically, the present invention relates to transgenic animal models for applications associated with TSPO-related normal physiology, diseases and disorders. The present invention features a transgenic nonhuman animal comprising cells with at least one copy of a non-functional, endogenous TSPO gene. Also disclosed are compounds for investigating or modulating TSPO-related functions.