rivaroxaban-containing composition and process for making a composition comprising rivaroxaban

摘要

rivaroxaban-containing composition and process for manufacturing a composition comprising rivaroxaban. The present invention relates to a composition comprising 5-chloro-n - ({(5s) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -1,3-oxazolidin-5 -yl} -methyl] -2-thiophene carboxamide as an active ingredient, manufactured by a melt extrusion method, the composition according to the present invention has a wide variety of advantages such as ensuring dissolution rate and bioavailability of the active ingredient, improving absorption drift depending on whether or not a patient has a meal, and ensuring stability during the manufacturing process The present invention further provides a method that can manufacture the composition.