antimicrobial and contraceptive composition that reduces the risk of transmission or infection by sexually transmitted disease through sexual activity

摘要

"Antimicrobial and contraceptive composition that reduces the risk of transmission of, or infection with, sexually transmitted disease through sexual activity involving a female vagina and a male penis, and a method of reducing the risk of transmission and infection with a sexually transmitted disease. transmitted through sexual activity involving a female's vagina and a male's penis. " Antimicrobial and contraceptive compositions are provided and methods that prevent and / or reduce the risk of transmission of sexually transmitted diseases through sexual activity and that also prevent and / or reduce the risk of pregnancy. the compositions contain (1) a matrix forming agent, (2) a bioadhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; the composition being suitable for application to the vagina; wherein the composition forms a semi-solid matrix when in contact with ejaculate (thereby trapping sperm and ejaculate microbes); the composition causing hardening of cervical mucus (thereby reducing the likelihood of sperm entry); the composition forms a bioadhesive layer on vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acid vaginal ph of less than about 5 in the presence of male ejaculate semen; and contraceptive compositions may also contain additional antimicrobial and / or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidines, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde copolymers, mandibenzene sulfonic acid formaldehyde copolymers, modified with h ~ 2 ~ so ~ 4 ~, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, and cyclopiroxolamine, and the like).