sustained release composition of superbavailable dvs (o-desmethylvenlafaxine succinate), use of superbavailable dvs composition, processes for treating depression in a subject and for reducing the side effects of desvenlafaxine in a subject, pharmaceutical packaging

摘要

An oral, highly bioavailable unit dosage form of O-desmethylvenlafaxine succinate (DVS) having a delayed release of at least about one hour and a sustained release over multiple hours to provide a total release of greater than about 85% within about 12 to about 14 hours is described. In one embodiment, the superbioavailable DVS composition has a delayed release of about two hours and a total release of greater than about 95% within about 12 to about 14 hours. Use of the formulation in treating depression and reducing the gastrointestinal side-effects of O-desmethylvenlafaxine (ODV) is also described.