MANMANMANMANMANMANMANMANMANMANMANMANMANMANMANMANMANMANMAND 3-5-4-(COCOCOCODUDUDUDUDUDUDUoxy)-2-hydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydroxhydrox2-(3-oxO-2,3-DIDIDIDIDIDIDIDIDI- 1,2-2-BenBenBenBenBenXaXaXaXaXaXaLO6-YYLOLOLOLOLOLOLOSPHINYYYLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOSPHPHPHPHPHINYYYYYYYYYYYYYYYYYYYYYYYLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLOLONICE INSTRUMENT AND INTERMEDIATION FOR THE PROCEDURE

摘要

A manufacturing method using as intermediate a 6-(halogenomethyl)-1,2-benzisoxazole-3(2H)-one derivative represented bythe general type in which R5 is a methyl strip substituted by one or more voluntarily substituted phenylamidesor a voluntarily submerged heterocyclic group containing oxygen; X represents a person of the equine species;may be used as a method for the safe and easy preparation of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl} propionic acid,which is useful as an anti-rheumatic agent,with high performance.