UNION 3,4-DIRECTED SYSTEM 1H-PYRAZOOL AND THEIR USE AS BRAKE RISKS EXTRACTED FROM CHINA (CDK) AND THE CROSS-3 SYSTEM OF FRENCH (GSK-3)

摘要

The present invention provides information on the use of molecular formula (0) or its salts or____or N-oxides or these___96 Such as the dependent kinase and glycogen synthase kinase -3 kappa kappa of cancer.In the formula: x (0) is a group of Nr4 R1a - or 5 melisse or requires a 16-person kappa alpha-beta____or an epsilon__________. A bond, SO2, C = O, NRG (C = O), where G is hydrogen or C1-C1-96 ______and hydroxyl groups or C1 to 4a__is a link or alpha___is a hydrogen or carbon atom.Three to twelve countries in the kappa alpha____or C18________________ Halogen (as selected).Fluorine, hydroxyl, amine, __ kappa alpha C1~4, single or double C1~4_______or heterocyclic groups, with 3 to 12 members, including 1 or 2 paired rings _delta p_kappa alpha P beta_____________963 4.__; or C1-4_______________ For example, fluorine or C1 ~ 4 alpha lambda. R3 is selected from hydrogen and the heterocyclic groups of 3-12 countries in the hydrogen or C1-4_______and R4. An optional pnpkappa, which is associated with halogen. For example, fluorine or C1 ~ 4 alpha lambda. (E).