Cells that co-express vitamin K reductase and vitamin K-dependent protein, as well as their use to improve the productivity of vitamin K-dependent protein

摘要

The present invention provides a host cell comprising a heterologous nucleic acid encoding a vitamin K epoxide reductase (VKOR) and a nucleic acid encoding a vitamin K dependent protein, wherein the nucleic acids encoding both the VKOR and Vitamin K dependent protein are expressed in said host cell. The invention also provides methods for improving the productivity of vitamin K dependent protein expression in a host cell.