PROCEDURE FOR THE MANUFACTURING OF GENETICALLY TRANSFORMED YEARS WHICH ARE ABLE TO MAKE A MOLECULE OF INTEREST AT A HIGH TITER

摘要

The subject of the present invention is a process for preparing a genetically modified yeast by multicopy integration of at least four expression cassettes, allowing the production of a molecule of interest at high titre. The subject of the present invention is also yeasts transformed according to said process, and the use thereof for producing hydrocortisone.