Substituted arylethylpyrimidine derivatives as isomeric modulators of metabotropic 5-glutamate receptors can be used in the treatment of schizophrenia, cognitive diseases, vulnerability X syndrome, autism, psychosis and obesity

摘要

the present invention relates to derivatives of formula (i) ethynyl wherein r1 represents a hydrogen or a halogen; r2 represents a c1 to c3 alkyl or - (ch2) m - ch3; n is 2 or 3; and m is 1 or 2, and their acid addition salts, pharmaceutical grade the s, racemic mixtures, or its enantiomers or optical isomers and stereoisomers, and / or related.it has been found that the compounds of general formula (i) are allosteric modulators of the metabotropic glutamate receptor subtype 5 in (mglur5) with improved properties for the treatment of schizophrenia, cognitive disorders, and fragile x syndrome and autism.