SALT FORMULATION OF GLYCYRRHIZIC COMPOUNDS IN THERMO REVERSIBLE GEL AND TRICHLOROACETIC ACID AS A KERATOLYTIC TOPICALLY APPLIED IN THE GENITAL TRACT IN MALES AND FEMALES WITH LESIONS CAUSED BY HUMAN PAPILLOMA VIRUS INFECTIONS AS WELL AS CANCER THEREIN.

摘要

The present invention refers to a novel formulation of ammonium salts of glycyrrhizic compounds such as glycyrrhizin, glycyrrhizic acid or glycyrrhetinic acid in a thermo reversible gel of the polyoxyethylene-polyoxypropylene-polyoxyethylene type as a vehicle at a 25% concentration, the compound being previously dissolved in propylene glycol as an absorption dissolvent or enhancer, at a compound concentration of from about 10, 20, 100mg/ml and to about 200 mg/ml of the active agent of the ammonium salts of glycyrrhizic acid; the compound includes a preserving agent such as methylparaben at a concentration of 0.1%, once the formulation is finished, the trichloroacetic acid being added at a cocnentration of 0.5 to 5.0% and finally the ph is maintained at a rate of 3-7, preferably at 3-5 due to physiological characteristics at a vaginal level. The invention is useful for the treatment of high and low grade intraepithelial squamous lesions related to Human Papilloma Virus recurrent infect ions of high and low oncogenic risk located at the inner and outer genital area such as cervix and vagina, and vulva, penis, anus, and rectum respectively, as well as cancer present in the aforementioned anatomic al regions in men and women.