Hydrogel-based sustained-release contact lens of drug, and drug-release method using a hydrogel-based contact lens of sustained-release drug

摘要

A daily disposable hydrogel-based contact lens for sustained drug release allowing sustained release of a dose of an anionic drug, in which the initial release amount within a 4 hour time period after initiation of use of the hydrogel-based contact lens is not more than 50% of the dose of the anion drug contained in the hydrogel-based contact lens, and is not less than 80% of the dose of the anion drug contained in the contact lens hydrogel-based contact and is released at least 14 hours after the start of use of the hydrogel-based contact lens, wherein the hydrogel-based contact lens comprises at least: (a) an anionic drug, (b) a combination of (i) and (ii) as hydrophilic monomers in which (i) is hydroxymethyl (meth) acrylate or 2-hydroxyethyl (meth) acrylate and (ii) is 2- (meth) acrylate 2,3-dihydroxypropyl hydroxypropyl or (meth) acrylate, and (c) monomers io The only ones that include a cationic monomer and an anionic monomer, the component ratio of the ionic monomers is not less than 5 mol% and is not more than 20 mol% with respect to the total amount of the compound monomers in the lens of hydrogel-based contact, and the content ratio of the anionic monomer is not less than 15 mol% and is not greater than 25 mol% with respect to the cationic monomer.