FOSAPREPITANT DIMEGLUMINE INTERMEDIATE, NEUTRAL FOSAPREPITANT, AND AMORPHOUS FOSAPREPITANT DIMEGLUMINE AND PROCESSES FOR THEIR PREPARATIONS

摘要

The present invention generally relates to a process for the preparation offosaprepitantdimeglumine intermediate and its use in the preparation of fosaprepitantdimeglumine; to aneutral form of fosaprepitant in a solid state and processes for thepreparation thereof; and toa stable amorphous fosaprepitant dimeglumine, having a stability attemperatures of about2°C to about 8°C and at a relative humidity below at least 60%;and a process for thepreparation thereof(see formula II)