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CO-TARGETING ANDROGEN RECEPTOR SPLICE VARIANTS AND MTOR SIGNALING PATHWAY FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER
CO-TARGETING ANDROGEN RECEPTOR SPLICE VARIANTS AND MTOR SIGNALING PATHWAY FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER
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机译:共靶向雄激素受体变异体和MTOR信号通路治疗抗降速前列腺癌
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摘要
The present invention provides methods, compositions, and combinations fortreating cancer via combined use of a compound of formula (I), and/or theirsubgenra, or apharmaceutically acceptable salt, tautomer or stereoisomer thereof, whereinR1, R2, R3, R8,R9, R11a, R11b, R11c, and R11d are as defined herein, and at least onetherapeutically activeagents selected from inhibitors of PI3K/AKT/mTOR pathway, active agentsassociatedwith the treatment of prostate cancer, and anticancer agents.(see formula I)
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