3-AMINO-PYRAZIN-2-YL CARBOXAMIDE AND 2-AMINO-PYRIDIN-3-YL CARBOXAMIDE DERIVATIVES AS POLO-LIKE KINASE 1 (PLK-1) INHIBITORS FOR THE TREATMENT OF CANCER

摘要

The present invention concerns 2-amino-pyridin-3-yl carboxamide and 3-amino-pyrazin-2-yl carboxamide derivatives of formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: • A is N or C-H, • Y is 0, S or one of the following groups : sulfoxide (-S(O)-), sulfone (- S(0)₂-) or N (R₃) with R₃being H, or an optionally substituted alkyl, acyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl or heteroaryl, • R₁ is H or an optionally substituted alkyl, acyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl or heteroaryl, or when Y is NR₃, R₁ and R₃ are together included into an optionally substituted 4 to 7-membered heterocycle or 8 to 10-membered heterobicycle, and • R₂ is any of the optionally substituted following groups: alkyl, acyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl, heteroaryl-alkyl or heteroaryl; for use as polo-like kinase 2 inhibitors for the treatment of cancer; as well as pharmaceutical compositions containing such a compound and processes to prepare such a compound.