NEW MODIFIED SYNTHETIC PEPTIDES DERIVED FROM HONEY PROTEINS IN CANCER CONTROL

摘要

Many trials were done to get more potent and stable anti-cancer peptides. Synthetic peptides derived from honey were modified to obtain promising peptides in cancer control. We modified the first two amino acids of the N-terminus and the last three amino acids of the C-terminus to be in the D-form instead of the L-form plus we added a NH2-group to the N-terminus and a COOH-group to the C-terminus. We found that the following peptides with the sequences from N-terminus to C-terminus have more potent anti-cancer effects plus more stability in human serum than the non-modified peptides of patent W0/2014/040605. Seven peptides similar to peptide F of patent W0/2014/040605 were postulated of more or less similar actions for further assessment experiments and maybe modification.