Photosensitizer for photodynamic diagnosis or therapy and photodynamic therapy using the same

摘要

The present invention relates to a photosensitizer for photodynamic diagnosis or treatment and a photodynamic therapy method using the same. The present inventors have found that the conventional photosensitizers are not decomposed in the body and thus they are difficult to be removed from the living body and thus cause nonspecific cytotoxicity. On the other hand, the photosensitizer for photodynamic therapy, hyaluronic acid and fullerene, The conjugated hyaluronic acid-fullerene conjugate and the hyaluronic acid-fullerene conjugate conjugated with a detectable compound that can be inserted into the DNA fragment are biodegradable and can be easily removed from the living body. In addition, by improving water solubility by adding water to fullerene, it exhibits cell killing ability through generation of oxygen with high optical properties, and increases particle stability in blood, thereby increasing drug efficiency and maximizing therapeutic effect. In addition, the photodynamic therapy method of the present invention can be applied to a first photodynamic therapy using a hyaluronic acid-fullerene conjugate, and a hyaluronic acid-fullerene conjugate conjugated with a detectable compound that can be inserted into a DNA fragment, , Or when a second photodynamic therapy is applied to the central necrosis of the tumor, cancer cells can be killed more effectively than the photodynamic therapy using only the hyaluronic acid-fullerene conjugate, and the therapeutic period can be shortened .