Manufacturing method of bio-implant compositions comprising particle-type acellular dermal matrix physically cross-linked with hyaluronic acid via electron beam

摘要

(I) lyophilizing the acellular dermis and then pulverizing it into a granular form; (Ii) adding hyaluronic acid and a solvent to the granular acellular dermis of step (i) and mixing them; And (iii) cross-linking the particle-type acellular dermis and hyaluronic acid by irradiating the mixture of step (ii) with an electron beam. The present invention also provides a composition for in vivo transplantation prepared by the above method. The composition for vital grafting according to the present invention can be maintained in the body for a longer time than a simple mixture of acellular allogenic dermis and hyaluronic acid, and can be utilized for repairing and repairing damaged tissue.;