QT Model for prediction of QT prolongation by drugs

摘要

The present invention relates to a pharmacokinetic / pharmacodynamic model for the evaluation of drug-induced QT prolongation syndrome in the course of the development of a new drug, and is intended to be used as a limit to the existing pharmacokinetic / pharmacodynamic model for predicting the QT prolongation syndrome, Induced QT prolongation syndrome by eliminating what did not distinguish the QTc interval change caused by the drug-induced QT prolongation syndrome. Therefore, the pharmacokinetic / pharmacodynamic model for the prediction of QT syndrome according to the present invention can be expected to more accurately predict the risk of drug-induced arrhythmia in the development of new drugs, thereby enhancing the stability of the drug.;