T CD40-CD40L Immunosuppression Composition for allogeneic- and Xenogeneic Transplantation Comprising Regulatory T cell and CD40-CD40L blockade

摘要

The present invention relates to a composition for inhibiting an immune response comprising an immunoregulatory T cell (Regulatory T cell) and a CD40-CD40L binding inhibitor. According to the present invention, the present invention enables the survival of pig islets transplanted into primates for a long period of time and shows high reproducibility, so that it is possible to overcome various immune rejection reactions occurring in recipients of allogeneic or xenogeneous organs Can be effectively used.;