KAI1 KAI1 PROTEIN CONTROLING CELL CYCLE OF HEMATOPOIETIC STEM CELL AND USES THEREOF

摘要

The present invention relates to a KAI1 protein that regulates the cell cycle of hematopoietic stem cells and, more particularly, to a composition for modulating the cell cycle of a hematopoietic stem cell comprising a KAI1 (CD82) polypeptide or a gene encoding the same, Or a pharmaceutical composition for therapeutic use. According to the present invention, KAI1 (CD82) is expressed only in the highest hematopoietic stem cell (LT-HSC) among the hierarchies of hematopoietic stem cells and LT-HSC can be obtained with high purity using KAI1. By high transplantation, various side effects of hematopoietic stem cell transplantation can be suppressed. In addition, KAI1 plays an important role in the quiescence of LT-HSC and is resistant to various stress (5-FU, Irradiation) cell damage by maintaining the quiescence of LT-HSC. And it is expected to be used as a therapeutic agent for hematologic tumor cells through cell transplantation.