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A STERILE AQUEOUS COMPOSITION BASED FOR INJECTION BASED ON THE BASED crosslinked HYALURONIC ACID AND HYDROXYAPATITIS FOR USE IN PLASTIC SURGERY
A STERILE AQUEOUS COMPOSITION BASED FOR INJECTION BASED ON THE BASED crosslinked HYALURONIC ACID AND HYDROXYAPATITIS FOR USE IN PLASTIC SURGERY
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机译:基于注射式交联透明质酸和羟磷灰石的注射用无菌水组合物在整形外科中的应用
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摘要
1. An acceptable sterile injectable aqueous composition for plastic surgery, in the form of a viscoelastic gel with cohesively bonded particles, comprising: i) crosslinked hyaluronic acid or one of its salts with a concentration in the range of 1 to 4% (weight / volume) ; moreover, cross-linking allows you to get a gel based on cross-linked hyaluronic acid with a structure called cohesively bonded; ii) hydroxyapatite with a concentration in the range from 5 to 60% (mass / volume), and hydroxyapatite is in the form of particles with an average size of less than or equal to 200 μm; moreover, the indicated sterile aqueous composition suitable for injection has viscoelastic properties, so that tan δ at a frequency of 1 Hz is less than or equal to 0.60.2. Acceptable for injection, a sterile aqueous composition according to claim 1, characterized in that the molecular weight of hyaluronic acid or one of its salts is in the range from 2.5 × 10 to 4 × 10 D. 3. An acceptable sterile injectable aqueous composition according to claim 1, characterized in that the composition is sterilized with moist heat. An injectable sterile aqueous composition according to claim 1, characterized in that the concentration of the crosslinked hyaluronic acid or one of its salts is in the range from 1 to 3% (weight / volume) and preferably in the range from 1.5 to 2.5% (mass / volume) .5. A suitable sterile injectable aqueous composition according to claim 1, characterized in that the concentration of hydroxyapatite is in the range of 10 to 50% (w / v) and preferably in the range of 20 to 40% (w / v). 6. An acceptable sterile injectable aqueous composition according to claim 1, characterized in that the average particle size of hydroxyapatite is less than or equal to 50 microns and greater than or equal to 10 microns. Acceptable for injection
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