Adenylyl cyclase incompetent in cyclic adenosine monophosphate, composition and methods for the treatment of cardiac insufficiency and improvement of cardiac function

摘要

The invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient having or at risk of having heart disease or heart failure, or decreased cardiac function, comprising: providing a cyclic adenosine monophosphate-incompetent (cAMP-incompetent) adenylyl cyclase type 6 (AC6) protein or polypeptide (also called an AC6mut), or an AC6mut-encoding nucleic acid or a gene operatively linked to a transcriptional regulatory sequence.