PREPARATION POSSESSING NEUROPROTECTIVE PROPERTIES IN EXPERIMENT AND METHOD OF OBTAINING THEREOF

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: group of inventions relates to field of creating preparation possessing neuroprotective properties in experiment, including biodegradable polymer matrix based on silk fibroin with immobilised peptide-agonist of PAR 1 receptor, released by activated protein C in ratio 99-99.9:0.1-1 wt % fibroin:peptide, as well as method for obtaining thereof.;EFFECT: application of the claimed group of inventions makes it possible to protect peptide -agonist of PAR 1 receptor, released by activated protein C from proteolysis and regulate rate of preparation output under conditions of experiment.;4 cl, 6 dwg, 1 tbl, 3 ex