首页> 外国专利> BORON-BASED 4-HYDROXYTAMOXIFEN AND ENDOXIFEN PRODRUGS AS TREATMENT FOR BREAST CANCER

BORON-BASED 4-HYDROXYTAMOXIFEN AND ENDOXIFEN PRODRUGS AS TREATMENT FOR BREAST CANCER

机译：硼基4-羟基他莫昔芬和内毒素类药物作为乳腺癌的治疗药物

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摘要

The present disclosure relates to boron-based 4-hydroxytamoxifen and endoxifen prodrugs and the synthesis of the same. Further, the present disclosure teaches the utilization of the boron-based 4-hydroxytamoxifen and endoxifen prodrugs in a treatment for breast cancer.whereinR₁isKF₃B, (HO)₂B, NaF₃B,wherein the R₁ substituent point of attachment is on the Boron atom; andR₂ is methyl or hydrogen.

机译：本公开涉及基于硼的4-羟基他莫昔芬和内皮昔芬前药及其合成。此外，本公开教导了基于硼的4-羟基他莫昔芬和内皮西芬前药在乳腺癌的治疗中的用途。 <图像文件=“ IMGA0001.GIF” he =“ 30” imgContent =“ chem” imgFormat =“ GIF” wi =“ 68” /> 其中R _{1 是 <图像文件=“ IMGA0002.GIF” he =“ 17” imgContent =“ chem” imgFormat =“ GIF” wi =“ 18” /> KF _{3 B，（HO）_{2 B，NaF _{3 B， <图像文件=“ IMGA0003.GIF” he =“ 21” imgContent =“ chem” imgFormat =“ GIF” wi =“ 70” /> <化学id =“ chema04” > <图像文件=“ IMGA0004.GIF” he =“ 36” imgContent =“ chem” imgFormat =“ GIF” wi =“ 48” /> 其中R _{1 取代基的连接点在硼原子上;和R _{2 是甲基或氢。}}}}}}

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公开/公告号EP3296300A1

专利类型
公开/公告日2018-03-21

原文格式PDF
申请/专利权人 XAVIER UNIVERSITY;
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申请/专利号EP20170182839
发明设计人 ZHENG SHILONG;WANG GUANGDI;JIANG QUAN;ZHONG QIU;ZHANG QIANG;
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申请日2013-03-05
分类号C07F5/05;A61K33/22;A61P35;C07F5/02;C07F5/04;A61K31/69;
国家 EP
入库时间 2022-08-21 13:15:36

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