ANTI-ANDROGENS FOR TREATING NON-METASTATIC, CASTRATION-RESISTANT PROSTATE CANCER

摘要

PROBLEM TO BE SOLVED: To provide methods for treating non-metastatic, castration-resistant prostate cancer.SOLUTION: Disclosed herein is administration of a therapeutically effective amount of an anti-androgen to a human male with non-metastatic, castration-resistant prostate cancer, wherein anti-androgen is selected from 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide, or 4-[7-[4-cyano-3-(trifluoromethyl)phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide.SELECTED DRAWING: None