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METHOD FOR PRODUCING AZILSARTAN ALKYL ESTER, AND METHOD FOR PRODUCING AZILSARTAN
METHOD FOR PRODUCING AZILSARTAN ALKYL ESTER, AND METHOD FOR PRODUCING AZILSARTAN
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机译:制备氮丙沙坦烷基酯的方法和方法
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摘要
PROBLEM TO BE SOLVED: To provide a method for producing azilsartan alkyl ester to be an intermediate of azilsartan by convenient operation and with high yield and high purity.;SOLUTION: High-purity azilsartan alkyl ester is produced by performing a cyclization reaction of alkyl 2-ethoxy-1-[[2'-(alkyloxy-carbonyloxycarbamimidoyl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate in a reaction solvent containing a C1-C8 alcohol.;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2018,JPO&INPIT
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