METHOD OF SCREENING FOR PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEPHROTIC SYNDROME, PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEPHROTIC SYNDROME, DIAGNOSTIC MARKER FOR NEPHROTIC SYNDROME, METHOD OF TESTING FOR NEPHROTIC SYNDROME, AND REAGENT FOR DIAGNOSING NEPHROTIC SYNDROME

摘要

PROBLEM TO BE SOLVED: To provide a simple and accurate method of screening for a prophylactic or therapeutic agent for nephrotic syndrome, a novel pharmaceutical composition for preventing or treating nephrotic syndrome, and a novel diagnostic marker for nephrotic syndrome.;SOLUTION: A method of the present invention for screening for a prophylactic or therapeutic agent for nephrotic syndrome comprises: a step 1 for adding pharmaceutical candidate substances to cells expressing a synaptic vesicle-associated molecule; a step 2 for measuring expression levels of the synaptic vesicle-associated molecule; and a step 3 for selecting a substance that increases the expression level. A pharmaceutical composition of the present invention for preventing or treating nephrotic syndrome contains a synaptic vesicle-associated molecule expression promoting substance or synaptic vesicle-associated molecular function promoting substance as an active ingredient. The present invention also relates to use of the synaptic vesicle-associated molecule as a diagnostic marker for nephrotic syndrome.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT