METHOD FOR ASSISTING RISK ASSESSMENT OF ONSET OF NON-HODGKIN LYMPHOMA

摘要

PROBLEM TO BE SOLVED: To provide a method of effectively and appropriately assessing the risk of onset of non-Hodgkin lymphoma including ATLL.;SOLUTION: An existence of at least one of G7340A, G7322A, and G7467A mutations of the HTLV-1 gene of a subject is detected. The non-Hodgkin lymphoma is adult T-cell leukaemia/lymphoma (ATLL). It is preferable to detect the existence of HLA-A*02 positivity in the subject. In ATLL carriers, the growth promoting action by viral genes (Tax and HBZ) and the inhibitory action by host immunity (mainly Tax-specific CTL) are in equilibrium. However, at the stage of onset, the expression of Tax decreases and accordingly the expression of HBZ increases. For example, when the G7340A mutation exists, the expression of Tax is low and the expression of HBZ is high.;SELECTED DRAWING: Figure 4;COPYRIGHT: (C)2018,JPO&INPIT