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Methods for treating obesity and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis using glucagon receptor antagonist antibodies

机译:使用胰高血糖素受体拮抗剂抗体治疗肥胖症和非酒精性脂肪肝或非酒精性脂肪性肝炎的方法

摘要

The present disclosure relates to methods for treating or preventing obesity and / or nonalcoholic fatty liver disease (NAFLD) and / or nonalcoholic steatohepatitis (NASH) using a glucagon receptor blocker. In various embodiments, the present disclosure provides for treating or preventing NAFLD / NASH using antagonistic antigen binding proteins, such as fully human antibodies, that specifically bind to and antagonize the function of the human glucagon receptor. Regarding the method. [Selection] Figure 3
机译:本公开涉及使用胰高血糖素受体阻滞剂治疗或预防肥胖和/或非酒精性脂肪肝疾病(NAFLD)和/或非酒精性脂肪性肝炎(NASH)的方法。在各种实施方案中,本公开内容提供了使用拮抗性抗原结合蛋白(例如完全人抗体)来治疗或预防NAFLD / NASH,所述抗原特异性结合蛋白并与之拮抗人胰高血糖素受体的功能。关于方法。 [选择]图3

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