Devices and methods for inhibiting stenosis, occlusion or calcification of natural heart valves, stented heart valves or bioprostheses

摘要

The present invention relates to stenosis, occlusion or calcification of a valve of a natural valve that develops a disease via the Lrp5 / Wnt pathway after implantation of a valve prosthesis or in the presence of elevated lipid due to elevated low density lipoprotein. The present invention relates to a method for suppressing crystallization. The present invention involves administering a combination of medications to target inflammation and target cell attachment, and a second drug to inhibit proliferation and calcification on elastic stents, gortex grafts or valvular membranes. . Combination therapy suppresses bioprosthesis and natural valve calcification with improved life of artificial materials including stents, natural valves and gortex covers. The valve prosthesis and / or gortex implant is mounted on an elastic stent or prosthesis such that the elastic stent is connected to the valve.