METHODS FOR PRODUCING TARGETING AGENTS FUNCTIONALIZED WITH DIBLOCK COPOLYMER FOR USE IN PREPARATION OF THERAPEUTIC TARGETING NANOPARTICLES

摘要

PROBLEM TO BE SOLVED: To provide methods for producing nanoparticles capable of coupling a targeting agent using pre-functionalized poly(ethyleneglycol) (PEG) as a macroinitiator for synthesizing diblock copolymers for drug delivery.SOLUTION: Provided is a method for producing a nanoparticle where the method comprises: providing a targeting agent; providing a functionalized PEG polymer; providing a targeting agent ligand; reacting the functionalized PEG polymer with the targeting agent to form a targeting agent-PEG polymer conjugate, and then mixing the targeting agent-PEG polymer conjugate with a second polymer and a therapeutic agent to form nanoparticles.SELECTED DRAWING: None