Classification of molecular phenotypes in patients with diseases associated with chronic inflammation

摘要

Diagnosing a molecular phenotype of a patient suffering from a disease associated with chronic inflammation, is claimed, where the molecular phenotype comprises subgroups of type 2 helper (Th2) high, Th2 low, type 1 helper (Th1) high and Th1 low, and a gene expression of globin transcription factor 3 (GATA3) and/or T-box transcription factor (Tbet) is measured in a biological isolate of the patient and is used for the assignment to a molecular phenotype of the disease. Independent claims are included for: (1) drugs for treating a molecular phenotype of a patient suffering from a disease associated with chronic inflammation; and (2) a kit for diagnosing a molecular phenotype of a disease associated with chronic inflammation, comprising at least one specific component for the quantitative determination of a protein- and/or mRNA-levels of GATA-3 and/or Tbet in a biological isolate of the patient.