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Method for establishment of bone marrow highly metastatic mouse breast cancer cell line of breast cancer
Method for establishment of bone marrow highly metastatic mouse breast cancer cell line of breast cancer
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机译:建立骨髓高转移性乳腺癌小鼠乳腺癌细胞系的方法
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摘要
PROBLEM TO BE SOLVED: To establish an establishing method of a marrow highly metastatic breast cancer cell strain of breast cancer in which a highly metastatic mouse 4T1E/M3 breast cancer cell strain is further improved and to provide a marrow highly metastatic breast cancer model animal using the established strain.SOLUTION: A marrow highly metastatic mouse breast cancer cell strain is established at a high ratio by employing means that: a mouse breast cancer cell 4T1E/M3 cell strain is used as a parental strain; cells having an excellent migration ability in a vertical direction are selected with a dual well comprising fine holes on a bottom part of an inner well; then the cells are subcutaneously administered to a mouse to obtain marrow cells from vertebrae; screening drug resistant strains from the cells; and the drug resistant strains are administered to a mouse. There is also provided a marrow highly metastatic breast cancer model animal in which the marrow highly metastatic mouse breast cancer cell strain is transplanted to a mouse.
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