3,4-dihydroxy-2- (3-methylbutanoyl) -5- (3-methylbutyl) -4- (4-methylpentanoyl) cyclopent-2-en-1-one derivative, substantially pure mirror image Isomeric compositions and related applications

摘要

The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, ()-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR, activate GPR120, inhibit inflammation, and treat conditions responsive to PPAR modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.