According to the present invention, unlike known production methods, it is possible to avoid the Ullmann condensation, in which the yield decreases with scale-up, by changing the starting material, and safely, the reaction yield 6-amino-9-[(3R) -1- (2-butinoyl) -3-pyrrolidinyl] -7- (4-phenoxyphenyl) -7,9-dihydro-8H-purine-8 -ON can be supplied.
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