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TREATING ATHEROSCLEROSIS BY REMOVING SENESCENT FOAM CELL MACROPHAGES FROM ATHEROSCLEROTIC PLAQUES
TREATING ATHEROSCLEROSIS BY REMOVING SENESCENT FOAM CELL MACROPHAGES FROM ATHEROSCLEROTIC PLAQUES
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机译:通过去除动脉粥样硬化斑块中的泡沫细胞巨噬细胞来治疗动脉粥样硬化
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摘要
Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. In advanced lesions, senescent cells promote features of plaque instability, including elastic fiber degradation and fibrous cap thinning, by heightening metalloprotease production. This invention provides methods and materials for treating arthritis by removing senescent cells in or around atherosclerotic plaques, thereby stabilizing the plaques, inhibiting rupture of the plaques and pathological sequelae that manifest as coronary artery disease.
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