ANTIFUNGAL NYLON-3 POLYMERS AND COMBINATION THERAPY USING THEM TO TREAT FUNGAL INFECTIONS

摘要

A method and corresponding pharmaceutical composition for inhibiting the growth of fungi. The method uses an antifungal composition containing as the active ingredient one or more nylon-3 copolymers having a formula:; or a salt thereof,wherein: each R is independently hydrogen or C₁-C₆-alkyl; each R¹, R³, R⁴, R⁵, and R⁶ are each independently selected from the group consisting of hydrogen or substituted or unsubstituted C₁-C₆-alkyl; each R² is C₁-C₆-alkylene; “A” is hydrogen or an amino-protecting group; “B” is hydroxyl or a carboxy-protecting group; and “X,” “Y,” and “Z” are positive numbers.